The technology behind the Oxford coronavirus jab could be harnessed to fight cancer, say scientists.
It could help trigger the immune system to fight tumours, an early study in mice shows.
A clinical trial of the jab in 80 patients with lung cancer, pairing it with immunotherapy, is set to start this year.
The British vaccine protects against Covid using a chimpanzee virus which delivers a genetic code carrying the instructions for a protein on the virus.
The technology behind the Oxford coronavirus jab could be harnessed to fight cancer, say scientists (stock image)
The goal is to get the body’s cells to make that protein, training the immune system to recognise the virus and fight it off.
Scientists realised the same technology could be used to get the body to make two proteins often found on tumours.
This flags up these proteins to white blood cells that can kill cancer cells.
Professor Adrian Hill, of the Jenner Institute at Oxford University, said: ‘This new vaccine platform has the potential to revolutionise cancer treatment.’
The mice study, carried out by the Ludwig Institute for Cancer Research, showed an 82 per cent greater reduction in tumour size after 36 days.
A similar vaccine used on 23 men with advanced prostate cancer, alongside immunotherapy, showed the treatment is safe and significantly reduced levels of PSA – a protein produced by prostate cancer cells – in almost a quarter of them.
The new vaccine targets proteins produced by a wide variety of tumour cells, so could help people with many different cancers, including breast cancer, bowel and bladder cancer, lung cancer and melanoma.
It helps to boost a treatment called anti-PD-1 immunotherapy, which takes the brakes off immune cells called CD8+ T cells so that they can invade and destroy tumours.
A clinical trial of the jab in 80 patients with lung cancer, pairing it with immunotherapy, is set to start this year (stock image)
This immunotherapy does not work for most people, often because they do not have enough of these important T cells to begin with.
The vaccine, which shows the body proteins from the tumours to flag them up, helps to recruit extra T cells.
The initial animal study, carried out by the Ludwig Institute for Cancer Research, in collaboration with Oxford University, was found to improve the success of treatment.
Compared to immunotherapy alone, the vaccine and immunotherapy achieved an 82 per cent greater reduction in tumour size after 36 days.
Mice had a 36 per cent chance of survival, up from 17 per cent, according to the results published in the Journal for ImmunoTherapy of Cancer.
The two-dose cancer vaccine uses different viruses to transport the genetic code it uses – first the chimpanzee virus used in the Covid vaccine and then a modified vaccinia ankara virus, which is a weakened virus usually used as a smallpox vaccine.
Tips to Find Low Priced Luxury Holiday Package Deals Fast
For most families, it has already been a common practice to spend the Holiday season in a foreign location. This is caused by the aviation market changes which have given a lot of benefits for people who travel a lot. Airfares going to different tourist destinations are becoming more inexpensive. What does this mean? If there is a perfect time to purchase luxury holiday package deals, now it the right time! Based on the market trend nowadays, you can save both money and time when you go for a luxury holiday. There are countless offers that combine travel and accommodation in one package which is a lot cheaper than getting separate deals. Aside from that, it is also risky to individually book the services that you need for the vacation. You might end up missing out on some important details of the trip. Unlike when you take advantage of luxury holiday package deals, you can be sure that everything is organized meticulously and according to what you really need. Nonetheless, you would still need to carefully select the package that would fit your needs. Review the following tips in getting packages that are reasonably priced. · Normally, luxury tour packages include accommodation, flight travel and transportation to individual tourist destinations. It would be best to choose the complete package so you won’t have to worry about other vacation elements. In addition to that, these are the packages that have the biggest discounts. · You can get big mark down prices, if you will purchase more packages. It is not a bad idea to share the wonderful moment with your loved ones. By doing so, you would not only enjoy, you will also save more money. You can even use your savings for other activities on your vacation. · It would be best to know how much you are willing to pay for the luxury tour packages. You can already work around your budget. You have to stick to your budget. If not, you might end up spending a lot and you will be left with less money for your vacation. · Prices may vary depending on the destination of the tour. You can do a research about places that are attractive yet inexpensive. There are thousands of destinations and you just have to choose wisely. · There are packages that include recreational activities. This means that you are paying for all the activities when you purchase these packages. The right thing to do is to make sure that the activities that are included would be the ones that you really enjoy. There is no sense in paying for activities that will not really make your vacation memorable. If you are going with friends, you should also consider their preferences so that you can be sure that everyone will enjoy the trip. There are other ways on how you can be sure that you are getting the best deal for your luxury holiday vacation. No matter how you choose to do it, you have to get adequate information about the packages. This will help you determine whether it is worth the price.