Successful test of cancer-killing `Trojan Horse´ drug…

Researchers have successfully tested a new drug which can kill cancer cells without damaging nearby healthy tissue – removing the need for chemotherapy.

Scientists at the University of Edinburgh combined the tiny cancer-killing molecule called SeNBD with a chemical food to trick the harmful cells into ingesting it.

Cancerous cells are ‘greedy’ and need to consume high amounts of food for energy and they typically ingest more than healthy cells, the experts said.

By coupling SeNBD with a chemical food compound it becomes the ‘ideal prey for harmful cells’ which ingest it ‘without being alerted to its toxic nature’.

Researchers have successfully tested a new drug which can kill cancer cells without damaging nearby healthy tissue - removing the need for chemotherapy

Researchers have successfully tested a new drug which can kill cancer cells without damaging nearby healthy tissue - removing the need for chemotherapy

Researchers have successfully tested a new drug which can kill cancer cells without damaging nearby healthy tissue – removing the need for chemotherapy

The drug was invented by University of Edinburgh researchers who compared it to a ‘Trojan Horse’, and its effects to a ‘metabolic warhead’.

The experimental study was carried out on zebrafish and human cells, but researchers say more studies are needed to confirm if it is a safe and swift method of treating early stage cancer and drug-resistant bacteria. 

Scientists hope the treatment will boost survival rates among cancer patients and spare many from damaging chemotherapy.

So far, it has only been used on glioblastoma, the most common brain cancer. 

SeNBD is also a light-activated photosensitiser, meaning it kills cells only after it is turned on by visible light.

This means a surgeon can precisely decide when they want to activate the drug, reducing the chances of it destroying healthy tissues and avoiding side-effects like hair loss caused by other anti-cancer agents, said the university.

The findings are published in the journal Nature Communications.

Lead researcher Professor Marc Vendrell, chair of translational chemistry and Biomedical Imaging at the University of Edinburgh, said: ‘This research represents an important advance in the design of new therapies that can be simply activated by light irradiation, which is generally very safe.

‘SeNBD is one of the smallest photosensitisers ever made and its use as a “Trojan horse” opens many new opportunities in interventional medicine for killing harmful cells without affecting surrounding healthy tissue.’

Dr Sam Benson, a post-doctoral researcher at the university, said the mechanism of the drug’s delivery means it is delivered through the ‘front door of the cell’ rather than having to ‘find a way to batter through the cell’s defences’.

The legend of the Trojan Horse in Greek mythology recounts the tale of Greek soldiers constructing a giant hollowed-out wooden horse in which they hid to gain access to the city of Troy, having pretended to desert the war.

The Trojans took the massive structure as a gift and ushered it inside the city walls, only for Greek warriors to emerge from inside and sack the city.

Link hienalouca.com

Advertising:

Tips to Find Low Priced Luxury Holiday Package Deals Fast

For most families, it has already been a common practice to spend the Holiday season in a foreign location. This is caused by the aviation market changes which have given a lot of benefits for people who travel a lot. Airfares going to different tourist destinations are becoming more inexpensive. What does this mean? If there is a perfect time to purchase luxury holiday package deals, now it the right time! Based on the market trend nowadays, you can save both money and time when you go for a luxury holiday. There are countless offers that combine travel and accommodation in one package which is a lot cheaper than getting separate deals. Aside from that, it is also risky to individually book the services that you need for the vacation. You might end up missing out on some important details of the trip. Unlike when you take advantage of luxury holiday package deals, you can be sure that everything is organized meticulously and according to what you really need. Nonetheless, you would still need to carefully select the package that would fit your needs. Review the following tips in getting packages that are reasonably priced. · Normally, luxury tour packages include accommodation, flight travel and transportation to individual tourist destinations. It would be best to choose the complete package so you won’t have to worry about other vacation elements. In addition to that, these are the packages that have the biggest discounts. · You can get big mark down prices, if you will purchase more packages. It is not a bad idea to share the wonderful moment with your loved ones. By doing so, you would not only enjoy, you will also save more money. You can even use your savings for other activities on your vacation. · It would be best to know how much you are willing to pay for the luxury tour packages. You can already work around your budget. You have to stick to your budget. If not, you might end up spending a lot and you will be left with less money for your vacation. · Prices may vary depending on the destination of the tour. You can do a research about places that are attractive yet inexpensive. There are thousands of destinations and you just have to choose wisely. · There are packages that include recreational activities. This means that you are paying for all the activities when you purchase these packages. The right thing to do is to make sure that the activities that are included would be the ones that you really enjoy. There is no sense in paying for activities that will not really make your vacation memorable. If you are going with friends, you should also consider their preferences so that you can be sure that everyone will enjoy the trip. There are other ways on how you can be sure that you are getting the best deal for your luxury holiday vacation. No matter how you choose to do it, you have to get adequate information about the packages. This will help you determine whether it is worth the price.

(Total views: 69 Time, 1 visits per day)

Leave a Reply