Coronavirus: Germany’s Angela Merkel backs Europe-first threat of Covid vaccine export ban

Boris Johnson tonight claimed the UK ‘wouldn’t dream’ of blocking exports of Covid jabs to the EU as he sought to defuse the vaccine trade war brewing on the continent.

Officials in Europe are threatening to ban supplies of AstraZeneca’s jabs from coming into the UK amid a row over millions of unclaimed doses of the British-made jab at a plant in the Netherlands. 

The Prime Minister, who is thought to be working behind the scenes to find a compromise with the EU, claimed Britain did not ‘believe in blockades of any kind of vaccine’.

Calling for unity at tonight’s Downing Street press conference, he added: ‘We are all fighting the same pandemic’.  

The European Commission will tomorrow extend powers to potentially block vaccine exports to Britain and other areas with higher vaccination rates than the EU.

France and Germany have both come out in favour of the EU-first policy, after the sluggish vaccine rollout on the continent has seen just 8 per cent of Europeans immunised.

French Europe Minister Clement Beaune, a close ally of President Macron, directly threatened exports to the UK today, telling France Info radio: ‘AstraZeneca says ”I am experiencing delays”, we say ”mobilise your plants for us and if you don’t, we will block exports to the UK”.’

German Chancellor Angela Merkel has come out in favour of a vaccines export ban if Europe can't get a handle on its struggling vaccine programme

German Chancellor Angela Merkel has come out in favour of a vaccines export ban if Europe can't get a handle on its struggling vaccine programme

German Chancellor Angela Merkel has come out in favour of a vaccines export ban if Europe can’t get a handle on its struggling vaccine programme

UK Prime Minister Boris Johnson has tried to talk European chiefs into an agreement or compromise over AstraZeneca vaccines being made on the continent but some leaders are pulling away and sticking to their Europe-first approach

UK Prime Minister Boris Johnson has tried to talk European chiefs into an agreement or compromise over AstraZeneca vaccines being made on the continent but some leaders are pulling away and sticking to their Europe-first approach

UK Prime Minister Boris Johnson has tried to talk European chiefs into an agreement or compromise over AstraZeneca vaccines being made on the continent but some leaders are pulling away and sticking to their Europe-first approach

Britain makes enough of the AstraZeneca vaccine in the UK to be self-sufficient but jumped at the opportunity to buy extra stocks from a factory in the Netherlands, which has angered politicians in Europe, where deliveries of the AZ jab have been smaller than expected

Britain makes enough of the AstraZeneca vaccine in the UK to be self-sufficient but jumped at the opportunity to buy extra stocks from a factory in the Netherlands, which has angered politicians in Europe, where deliveries of the AZ jab have been smaller than expected

Britain makes enough of the AstraZeneca vaccine in the UK to be self-sufficient but jumped at the opportunity to buy extra stocks from a factory in the Netherlands, which has angered politicians in Europe, where deliveries of the AZ jab have been smaller than expected

EUROPE FACING ‘NEW PANDEMIC’ AS THIRD WAVE HITS 

Germany is going back into lockdown over Easter with Angela Merkel warning ‘we are in a new pandemic’ as mutant Covid strains cause cases to spike, with France seeing infections double in a week.

Europe’s coronavirus third wave, which has been gathering pace for weeks now, has reached crisis point over the last few days with leaders across the continent forced to reimpose strict measures to keep cases down.

Mrs Merkel announced last night that all non-essential shops in Germany will be closed over the Easter period with church services moved online and public gatherings banned as infections rise ‘exponentially’.

Meanwhile the head of France’s hospital federation warned that case figures are ‘exploding’ in his country and the health system is heading for an ‘unprecedented violent shock’ in about three weeks unless strong action is taken.

Frederic Valletoux spoke out after Prime Minister Jean Castex imposed tough measures on 16 French regions including the cities of Paris, Lille and Nice last week – measures which experts say do not go far enough.

In Spain, experts have begun warning of a fourth wave of Covid after deaths from the virus rose to 633 on Monday compared to 298 a week ago. The country is currently under a nationwide curfew and while exact measures vary from region to region, most have imposed curbs on movement, gatherings, and closed some businesses.

Covid cases and deaths also remain high in Italy where new lockdown measures were imposed across much of the country last week, although infection data has begun trending downwards since then.

Mrs Merkel last night pointed to the so-called Kent variant of coronavirus as being responsible, saying: ‘Essentially, we have a new virus… it is much deadlier, much more infectious and infectious for much longer.’

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Chancellor Angela Merkel threw her support behind the move today and the threat of a ban on exports to third countries like Britain that has been advocated by European Commission president Ursula von der Leyen – her former defence minister.

A senior French minister also explicitly warned exports of the jab to Britain could be halted unless more were supplied to EU nations.

In a sign of how far Europe is behind the UK, Emmanuel Macron announced today that the age from which people can be vaccinated against Covid-19 virus would be lowered to 70 from 75 from Saturday.

French Europe Minister Clement Beaune, a close ally of President Macron, directly threatened exports to the UK today, telling France Info radio: ‘AstraZeneca says ”I am experiencing delays”, we say ”mobilise your plants for us and if you don’t, we will block exports to the UK”.’

He said that such a move would be discussed at a European summit at the end of this week, adding: ‘We want to avoid that AstraZeneca doses produced in Europe go to Britain when we are not receiving anything.’ 

The hardline approach of some EU states –  which has been attacked as ‘vaccine nationalism – has created a schism in the block, as other countries including Ireland warning it would be disastrous. 

Tensions are surging as world leaders argue over millions of doses of the Oxford jab that are reportedly being stored in a factory in the Netherlands.

Neither the EU nor UK has an obvious claim to the stockpile but both want a slice of it. Boris Johnson is allegedly considering an offer to split the stash with the EU to avoid a blockade. 

Mrs Merkel this morning said: ‘I support Commission President Ursula von der Leyen. We have a problem with AstraZeneca.’

And one of her ministers also deepened the ongoing row with an attack on the Anglo-Swedish firm.

‘For us, it is very, very important that everyone lives up to their responsibilities,’ Europe minister Michael Roth said this morning.

‘Everyone has to stick to their commitments, this is clearly also true for companies that have promised the delivery of vaccine contingents.’

The row appears to be revolving around vaccine supplies being made at a factory in Leiden, Netherlands. Neither the UK nor EU is currently using the vaccine the plant is making but Britain has ruffled feathers by importing some to add to stocks being made in its own factories at a time when the EU claims AstraZeneca is under-delivering in Europe. 

Although the UK is miles ahead in its vaccination programme, officials are still worried about the disruption an EU ban would cause. A source in Whitehall told The Times ‘we’re very worried about it’.   

Merkel’s comment comes as European leaders are divided over whether to press ahead with an extraordinary ban on vaccine exports to Britain.

Brussels sources confirmed that the EU is ready to block a shipment of the AstraZeneca vaccine to the UK from a plant in the Netherlands.

But the issue has triggered a major rift among leaders of member states ahead of a key summit on Thursday.

One senior EU official described internal talks on the issue as a ‘total s*** show’.

Boris Johnson has launched a diplomatic offensive in recent days in a bid to head off a ban which could delay the UK’s vaccine programme.

The PM has sent his senior adviser Lord Lister to India for talks on unblocking a shipment of five million doses of the AstraZeneca vaccine delayed last week on orders of the New Delhi government.

Government sources confirmed that the Prime Minister held private talks with Angela Merkel and Emmanuel Macron on Sunday in a bid to defuse the row.

But he appears to have failed as both have come out in favour of the ban if Europe can’t negotiate a better supply deal with AstraZeneca. 

Mr Johnson played down the threat yesterday, saying he was ‘reassured by talking to EU partners over the last few months that they don’t want to see blockades’.

However, some ministers are alarmed by the protectionist rhetoric emerging from the EU and fear Brussels will press ahead with the ban in a bid to distract attention from the dismal performance of its own vaccine rollout.

One insider said: ‘It is madness, but for some politicians it is easier to have a row with AstraZeneca and Britain than to have people focusing on the contracts they didn’t get.’  

Mrs von der Leyen warned last week she was ready to block vaccine exports to the UK as part of a ‘Europe first’ agenda designed to ensure that AstraZeneca and other drug firms meet their commitments to the bloc before supplying others.

A spokesman for Mrs Merkel said factories in EU countries had exported 34million doses to 30 countries, but that those in Britain and the US had shipped ‘almost nothing’. During a phone call on Sunday she told Mr Johnson that Mrs von der Leyen was right to be considering ways to further restrict shipments.

French Europe Minister Clement Beaune, a close ally of Mr Macron, said Paris also backed Mrs von der Leyen’s plans. ‘This must be the strategy of a Europe that moves faster and defends its interests: produce more, enforce contracts, and control exports,’ he said.

But a string of other EU countries are alarmed by the idea of blocking exports, amid fears it could do serious international damage to its reputation as a place to do business. Irish Taoiseach Micheal Martin warned that a ban would be ‘a very retrograde step’ which would prove counter-productive.

Mr Martin, who could face the prospect of the EU imposing a hard border with Northern Ireland to prevent vaccines entering the UK, said he had made it ‘very clear’ to fellow leaders he was opposed.

‘They’re not EU vaccines,’ he said. ‘These are vaccines paid for by other countries that are manufactured in Europe.’

President of the EU Commission, Ursula von der Leyen, has been leading calls for Europe to stop shipping Covid vaccines to other countries before it can provide for its own citizens

President of the EU Commission, Ursula von der Leyen, has been leading calls for Europe to stop shipping Covid vaccines to other countries before it can provide for its own citizens

President of the EU Commission, Ursula von der Leyen, has been leading calls for Europe to stop shipping Covid vaccines to other countries before it can provide for its own citizens

The row appears to be revolving around vaccine supplies being made at a factory in Leiden, Netherlands. Neither the UK nor EU is currently using the vaccine the plant is making but Britain has ruffled feathers by importing some to add to stocks being made in its own factories at a time when AstraZeneca is under-delivering in Europe

The row appears to be revolving around vaccine supplies being made at a factory in Leiden, Netherlands. Neither the UK nor EU is currently using the vaccine the plant is making but Britain has ruffled feathers by importing some to add to stocks being made in its own factories at a time when AstraZeneca is under-delivering in Europe

The row appears to be revolving around vaccine supplies being made at a factory in Leiden, Netherlands. Neither the UK nor EU is currently using the vaccine the plant is making but Britain has ruffled feathers by importing some to add to stocks being made in its own factories at a time when AstraZeneca is under-delivering in Europe

The Netherlands also opposes the jab ban, with Dutch PM Mark Rutte pushing for emergency talks between Mr Johnson, Mrs von der Leyen and AstraZeneca to thrash out a compromise.

UK COULD RETALIATE BY BLOCKING EXPORTS FROM YORKSHIRE FACTORY

A British chemicals maker could disrupt the EU supply of Pfizer jabs if the bloc tries to bring in an export ban.

Croda International, based in Snaith, East Yorkshire, makes key ingredients for the fatty droplet used to deliver the genetic code within the vaccine into the body.

This has reportedly allowed Pfizer to warn EU leaders that production at its main factory in Belgium could ‘grind to a halt’ within weeks if the UK stopped Croda deliveries from crossing the Channel. 

Croda, better known for making ingredients in shampoo and sun cream, has a five-year deal with Pfizer which it has said will boost sales by at least £90million this year.

The contract means there could be an option to fight back if the EU does stop vaccine exports to the UK. 

A spokesman for Croda, which does not make the vaccine ingredients in Snaith but elsewhere in the UK, said the company ‘is supplying lipid components manufactured in the UK and the US to multiple Pfizer facilities’.

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EU sources yesterday suggested the first action against the UK was likely to be a block on the export of AstraZeneca vaccines from the Halix plant in the Netherlands.

The Dutch plan would see No 10 agree to free up some production capacity at the plant, which currently supplies only Britain, to make jabs for Europe as well.

A senior Dutch government source said Mr Rutte wants to avoid a ‘lose-lose scenario’ where Brussels forces his country to block exports: ‘We must avoid a tipping point whereby exporting to third countries becomes problematic.’

Belgium also opposes the ban, fearing it could hamper supply chains worldwide. The Pfizer jab is produced there.

UK sources played down the idea of a compromise that would allow the sharing of vaccines produced at the Halix plant. A source said there had been ‘no indication of that’. Health sources insisted that the bulk of the Britain’s AstraZeneca supplies are manufactured in the UK.

The PM’s spokesman said: ‘We have said throughout the vaccination programme that supplies will fluctuate, but we remain confident in our supplies.’

However, one independent analysis suggested a total EU export ban could push the UK’s vaccination programme back by two months, potentially delaying Mr Johnson’s road map for lifting the Covid lockdown.

Whitehall sources played down this estimate but confirmed ministers had been warned a ban by the EU could hit supplies during May and June.

Vaccine supplies are already due to dip next month because of the delay to the shipment from India.

Downing Street said the vaccine rollout had to remain an ‘international effort’.

The PM’s spokesman told reporters Britain expects the EU to continue to stand by its commitment, adding: ‘It’s important that the whole world works together.’

US health chiefs accuse AstraZeneca of providing ‘outdated’ information from its vaccine trial – when it claimed the shot was 79% effective – in a bid to get approval in America

US health chiefs have accused AstraZeneca of sending ‘outdated information’ as part of an application to get its Covid vaccine approved for use on Americans.

The drug giant, which is manufacturing Oxford University’s jab, revealed yesterday that a US-specific trial found the vaccine prevented 100 percent of hospital admissions and deaths from Covid, along with 79 percent of all symptomatic infections. It said it hoped to get a licence from drug regulators within weeks.

Experts on the Data and Safety Monitoring Board, a secretive committee inside the National Institutes for Health that is vetting Covid vaccines, raised the alarm yesterday when AstraZeneca announced interim results.

The issue only came to light when the National Institute of Allergy and Infectious Diseases (NIAID) put out an ‘unprecedented’ public statement accusing the drug-maker of not giving watchdogs the full details from a study of the jab, urging the firm to share more information ‘as soon as possible’.

Dr Fauci called the NIAID note ‘quite harsh’ and assured Americans that AstraZeneca’s ‘data really are quite good’ in a Tuesday Good Morning America interview. 

But, he added: ‘It really is unfortunate that this happened. This is really what you call an unforced error because the fact is this is really very likely a very good vaccine, and this kind of thing does…nothing but really cast some doubt about the vaccines and maybe contribute to the hesitancy [of Americans to get the shot].’ 

The hiccup is latest in a string of PR disasters for AstraZeneca, which has faced constant criticism over its jab with European officials first claiming it didn’t work on older people and later that it caused blood clots – neither of which turned out to be true. UK and EU officials are now rowing over supplies.  

Real-world data proves that the vaccine is protecting people against Covid in the UK, which has given the jab to over 13 million people since it was approved in January. It means any updated figures are unlikely to change the regulator’s decision but must be examined thoroughly. 

Experts reacting to the NIAID’s statement released last night described it as ‘unusual’ and said airing grievances in the public domain was ‘unprecedented’. They criticized AstraZeneca for ‘confusing’ officials with the way it was sending its data. 

So far, there is no indication that the scuffle over AstraZeneca’s press release will change its plans to ask the FDA for Food and Drug Administration (FDA) to authorize its vaccine in the coming weeks, or the shots odds of getting the expected green light from regulators next month. 

AstraZeneca, whose North American headquarters (pictured) are in Wilmington, Delaware, was asked Monday for more data

AstraZeneca, whose North American headquarters (pictured) are in Wilmington, Delaware, was asked Monday for more data

AstraZeneca had hoped that their vaccine would be granted FDA approval in the coming weeks, but that may now be delayed

AstraZeneca had hoped that their vaccine would be granted FDA approval in the coming weeks, but that may now be delayed

AstraZeneca, whose North American headquarters (pictured left) are in Wilmington, Delaware, was asked Monday for more data. Pictured right, vials of the firm’s vaccine

However, the FDA had already said AstraZeneca would likely face more scrutiny during its review meeting and process. 

And the allegedly ‘outdated’ data in Monday’s press release will undoubtedly be added to regulators’ list of questions. 

The full statement read: ‘Late Monday, the Data and Safety Monitoring Board (DSMB) notified NIAID, BARDA, and AstraZeneca that it was concerned by information released by AstraZeneca on initial data from its Covid vaccine clinical trial. 

‘The DSMB expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data. 

‘We urge the company to work with the DSMB to review the efficacy data and ensure the most accurate, up-to-date efficacy data be made public as quickly as possible.’

Covid vaccines can’t be rolled out in the US until they are approved by the FDA and the Centers for Disease Control (CDC), who rely on independent committees such as the DSMB to rigorously review the evidence. 

The DSMB – which is run through the NIAID – is made up of around 10 to 15 leading scientists and statisticians who have no ties to the Government or the drug firms making the jabs. 

‘It is not unknown for a [regulator] to disagree with investigators over interpretation of trial results but it is usually done in private, so this is unprecedented in my opinion,’ said Professor Stephen Evans, a vaccines expert at the London School of Hygiene & Tropical Medicine. 

‘I have said frequently that “headline” estimates of efficacy being compared between trials is very unreliable.

‘The DSMB [Data and Safety Monitoring Board] has responsibility essentially for safety of participants, not efficacy unless it is either so high or so low or negative that it is unethical to continue to randomize, so in some senses they might be seen to be exceeding their brief… 

‘One explanation might well be that this trial is currently being conducted when there is a large amount of a new variant about more recently, and, as might be expected, the efficacy against that variant might be less, so more recent data shows reduced efficacy. Of course the other vaccines may also show such reduced efficacy and we don’t know by how much.

‘It does not leave me concerned particularly unless they had found a safety issue that was being hidden, which does not appear to be the case.’ 

Dr Peter English, former editor of Vaccines in Practice Magazine and a former British Medical Association official, said the statement was ‘problematic in various ways’. 

He said: ‘In my opinion this is shamefully bad communication by NIH as with their lack of clarity they have left room for speculation which could be damaging for vaccine uptake.’

And Dr Stephen Griffin, an associate professor of medicine at the University of Leeds, said the issue ‘highlights the importance of data being provided at the same time as summaries being made public’. 

He added: ‘Naturally, the news yesterday was taken in good faith and the issues raised by the DSMB may be a mere technicality, yet this won’t be clear until we have full disclosure. 

‘Nevertheless, we must ensure that issues such as this are dealt with appropriately and that idle speculation is not seized upon by groups seeking to undermine faith in vaccination programmes.’

Oxford University yesterday published interim results of a trial done in the US, Chile and Peru that found its jab prevented 100 percent of severe Covid cases and 79 percent of all symptomatic infections.

It had been carried out because US regulators the FDA wanted a trial done on Americans before it would approve the jab, choosing not to use data from Oxford’s tests in the UK, South Africa and Brazil.  

And the study found the vaccine works just as well in over-65s as it does in younger people – it was the largest one so far conducted on older people, including more than 6,000 of them.

It isn’t the jab you need to fear – even mild Covid can trigger deadly clots 

Three days after testing positive, Robin suddenly felt so weak while out in the garden he couldn’t lift his arms to use the hedge clippers

Three days after testing positive, Robin suddenly felt so weak while out in the garden he couldn’t lift his arms to use the hedge clippers

Three days after testing positive, Robin suddenly felt so weak while out in the garden he couldn’t lift his arms to use the hedge clippers

Robin McNelis’s Covid-19 symptoms were so mild he didn’t know he’d had the disease.

It was only when a routine test at the hospital where he works as a respiratory physiotherapist came back positive that he found out his headache and fatigue were caused by the virus.

‘I was surprised to be told I had tested positive and should stay off work,’ says Robin, 47, who lives in Stapleford Abbotts, Essex, with his wife Nikki, 45, a project manager, and daughter Maya, 13.

‘I’d had no temperature or dry cough, but had lost my senses of taste and smell. I thought I’d got off lightly.’

But three days after testing positive, Robin suddenly felt so weak while out in the garden he couldn’t lift his arms to use the hedge clippers.

‘I lost my balance and felt dizzy, falling to the ground, twice,’ he says. ‘I sat down on a garden bench and immediately fell asleep for about five minutes. Then I got up and went back into the house, but struggled to walk up the stairs.’

None of this made sense. As a seasoned marathon runner, Robin was exceptionally fit. But the problems continued. He had to keep stopping when walking uphill, and felt a tightness across his chest and back when exercising.

After three weeks off, he returned to work at the private Wellington Hospital in London. However, he was still struggling with fatigue, chest pain and weak legs, so he was referred for a telephone assessment with a GP.

‘The GP asked me to measure my blood oxygen levels after climbing the stairs,’ says Robin, who used a pulse oximeter, which measures blood oxygen levels by sending light through the tiny blood vessels in the fingertip.

‘My levels were good but, two hours later, I was still short of breath,’ he recalls.

A respiratory consultant sent Robin for a lung scan, which revealed that a small blood clot was causing the symptoms. Robin was told that the virus had made his blood ‘sticky’, encouraging blood cells to clump together to form a clot, which can be fatal if it blocks blood flow to the lungs.

Smaller clots, as in Robin’s case, can cause breathlessness as well as chest pain. ‘They weren’t sure if the clot had formed in the lung, or whether it was a clot that had developed in the deep veins of the legs or pelvis, that had broken off and travelled to the lungs,’ says Robin.

He was put on blood thinners to disperse the clot and prevent more forming. But he was fortunate that the outcome wasn’t far worse. 

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The trial — which involved 32,000 people in total — also confirmed the vaccine doesn’t increase the risk of blood clots, which is a confidence boost after safety concerns in Europe rattled public faith in the jab last week. 

Two doses were given four weeks apart in the study and the effectiveness of a single dose was not reported. Full results from the trial are expected to be published later in the year. 

Trump’s administration made a deal with AstraZeneca last year for 300 million doses and the federal government is currently sitting on nearly 30million which can’t be used until the shot is authorized by the FDA. 

But this process has been delayed now, too, with officials having to wait until AstraZeneca sends the specific data they want. It is unclear how much of a delay the issue will cause, but the authorisation had been expected in April.

Experts said the news about the hold-up was concerning.

Professor Francois Balloux, a biologist at University College London, said: ‘This is a highly unusual statement by the US National Institute of Allergy and Infectious Diseases (NIAID). 

‘It comes close to accusing Oxford/AZ of having willfully misrepresented some results from their recent US vaccine trial.’

And Professor Angela Rasmussen, a virologist at Georgetown University, said: ‘If nothing else Oxford/AstraZeneca continues their perfect record of sharing trial data in the most confusing way possible.’ 

AstraZeneca said it still expected to get approval for the vaccine and one of its vice-presidents, Ruud Dobber, said on CNBC yesterday: ‘Assuming that the approval will take place in a fast way, we hope to deliver 30million doses instantly after the EUA [Emergency Use Approval] for Americans to get vaccinated.’  

Oxford’s Professor Andrew Pollard, who runs the vaccine trials, said the results were ‘remarkable’, and its inventor Professor Sarah Gilbert said she was ‘very pleased’.

Dean of Brown University’s School of Public Health, Dr Ashish Jha, called the results ‘fabulous news’ in a tweet and told the Today Show that the AstraZeneca shot is the ‘best ticket towards vaccinating the world.’  

The jab-makers were in need of good press after the past fortnight saw more than a dozen European countries shun the jab amid fears it could cause blood clots on the brain – on which most have now backed down, although Sweden, Denmark and Norway are still hesitating and refusing to use it. 

Meanwhile, Boris Johnson is preparing to call for EU leaders to shun ‘vaccine nationalism’ amid fears they will ban exports of vaccines because AstraZeneca is delivery on expectations in Britain but not in Europe, where it has allegedly only provided a third of the number of doses that were expected by the end of March.

Britain will also have to cope with five million fewer doses of the jab than expected in April because an expected shipment from India has been cancelled. 

This is expected to mean the vaccine drive, which gave out a record 844,285 jabs on Sunday, will have to stick mainly to second doses instead of new patients.

Some 32,449 people across all age groups took part in the phase three trial in the US, Chile and Peru, with a total of 141 cases of symptomatic Covid reported. 

Around two thirds of all the participants had the real vaccine – 21,583 – and the rest had a fake jab so the effects could be compared. Full results of the trial have not yet been published.

The initial results showed that among people aged 65 and over, there was 80 percent protection against developing symptomatic Covid, Oxford said.

This comes after officials in Europe, who had smeared the vaccine on yet another occasion, claimed that the vaccine didn’t work on people over 55 and tried to prevent it being used on elderly people.

The US trial initially found that the Oxford/AstraZeneca vaccine was more effective than expected after results from the UK trial – while both found it to be 100 percent effective at preventing hospital admission or death, the US one saw it prevent 79 percent of all infections compared to 76 percent in the UK

The US trial initially found that the Oxford/AstraZeneca vaccine was more effective than expected after results from the UK trial – while both found it to be 100 percent effective at preventing hospital admission or death, the US one saw it prevent 79 percent of all infections compared to 76 percent in the UK

The US trial initially found that the Oxford/AstraZeneca vaccine was more effective than expected after results from the UK trial – while both found it to be 100 percent effective at preventing hospital admission or death, the US one saw it prevent 79 percent of all infections compared to 76 percent in the UK

EUROPE’S UNPROVEN BLOOD CLOT CLAIMS SHAKE PUBLIC FAITH IN OXFORD’S JAB

Confidence in Oxford/AstraZeneca’s Covid-19 vaccine has plunged across Europe, polls show.

European leaders paused the rollout of the jab last week over fears it caused blood clots.

The European Medicines Agency later said the vaccine was not associated with a higher clotting risk.

Nevertheless, more people in France (61 percent), Germany (55 percent) and Italy (43 percent) now believe the jab is unsafe, according to YouGov.

In France, this was a jump of 18 points since February, while in Italy it was a mammoth 27-point rise.

Faith in the vaccine in the UK was dented less but still fell. Nine percent of people said the jab was unsafe, a jump of four points.

But more than three quarters of Britons still say both the AstraZeneca and Pfizer jabs are safe.

YouGov lead data journalist Matt Smith said the European leaders’ concerns over the vaccine undoubtedly damaged its reputation.

He said: ‘Not only have we seen considerable rises in those who consider it unsafe in the last two weeks in Europe, the AstraZeneca vaccine continues to be seen as substantially less safe than its Pfizer and Moderna counterparts.

‘With a third wave of infections potentially emerging now across the Channel, officials everywhere will be worried if ongoing rows about AstraZeneca’s vaccine ends up damaging the rollout.’

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Overall the study, which officials said was incomplete, found that the effectiveness of the jab against symptomatic Covid was even higher than it had been in the original trials that took place in the UK, South Africa and Brazil.

‘These results are great news as they show the remarkable efficacy of the vaccine in a new population and are consistent with the results from Oxford-led trials,’ said Professor Pollard.

‘We can expect strong impact against COVID-19 across all ages and for people of all different backgrounds from widespread use of the vaccine.’ 

AstraZeneca has not yet published the full results of the trial, but its press release does not address whether or not the US trial screened participants for variants. 

The older ‘wild-type’ coronavirus is still dominant in the US, but the UK’s B117 variant is gaining ground, and the Centers for Disease Control and Prevention (CDC) lists four additional variants as ‘concerning.’ 

In prior trials, the AstraZeneca shot was equally effective against B117, and worked well in Brazil where the P1 variant is dominant. 

But it performed poorly in South Africa, where the B1351 variant is dominant. 

Nonetheless, US health authorities are eager to add a fourth vaccine to the American arsenal. 

AstraZeneca’s shot has already been authorized in more than 50 countries around the world, and has helped the UK’s vaccination campaign to race ahead of the America’s.  

AstraZeneca’s US trial got a late start compared to its other global tests, beginning on August 28. 

Trials were also protracted after the death of a participant in Brazil last year.

American regulators dragged out the trial pause even after other countries resumed their tests. AstraZeneca’s trial wasn’t allowed to resume for more than six weeks.  

After European leaders this month claimed people were developing brain blood clots and even dying after having the AstraZeneca vaccine, inspectors looked at the risk of blood clots and found it was not increased at all.

They looked at a specific condition that had scared officials in Germany, called cerebral venous sinus thrombosis, and found there wasn’t a single case recorded in the clinical trial. 

The European Medicines Agency itself – which first launched an investigation and triggered panic across the continent – last week admitted there was no proof of a link to blood clots and backed down on its warning.

Health officials around the world, including Britain’s regulator the MHRA and the World Health Organization, have urged countries to keep using the vaccine to stamp out coronavirus.

Professor Sarah Gilbert, the Oxford scientist who invented the jab, said on BBC Radio 4 today: ‘I’m very pleased to see these results.

‘Another large trial in different countries to what we had before again reporting on the safety and high efficacy of this vaccine, so it’s really good news to see that.’

She added: ’20 percent of people in this trial were over the age of 65 and there was no drop in protection for those people. It was just as good in the over-65s as it was in the younger people and that’s very clear from this trial.’  

On Europe’s concerns, Professor Gilbert said: ‘I’d say the balance remains hugely in favour of using this vaccine. Across Europe there are thousands of deaths a day occurring from COVID.

‘It’s really important that we get the chance to protect people as quickly as possible, this vaccine is available for use in Europe and it will save lives.’ 

AstraZeneca said leaving an interval longer than four weeks – as is happening in the UK – can increase efficacy and ‘accelerates the number of people who can receive their first dose’.

This is understood to be because it allows the body to cement the immunity from the first dose before the second – the booster dose – provokes a second, separate reaction and lets the already established protection strengthen itself. 

As part of an agreement with Oxford, AstraZeneca is supplying the vaccine on a not-for-profit basis for the duration of the pandemic and in perpetuity for low and middle-income countries.

The news comes as polling for YouGov suggests confidence in the safety of the vaccine has dropped in the last two weeks in Spain, Germany, France and Italy.

Some 55 percent of Germans said the AstraZeneca vaccine is unsafe while 32 percent said it is safe.

AstraZeneca’s vaccine was already seen as unsafe in France but concerns have increased even further, with 61 percent now saying it is unsafe while 23 percent say it is safe, according to the survey of almost 9,000 people in seven countries.

More than a dozen European countries suspended use of the vaccine over concerns about blood clots, although most have now resumed its use.

The European Medicines Agency and the World Health Organization (WHO) have ruled that the AstraZeneca jab is safe and effective. 

Link hienalouca.com

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Tips to Find Low Priced Luxury Holiday Package Deals Fast

For most families, it has already been a common practice to spend the Holiday season in a foreign location. This is caused by the aviation market changes which have given a lot of benefits for people who travel a lot. Airfares going to different tourist destinations are becoming more inexpensive. What does this mean? If there is a perfect time to purchase luxury holiday package deals, now it the right time! Based on the market trend nowadays, you can save both money and time when you go for a luxury holiday. There are countless offers that combine travel and accommodation in one package which is a lot cheaper than getting separate deals. Aside from that, it is also risky to individually book the services that you need for the vacation. You might end up missing out on some important details of the trip. Unlike when you take advantage of luxury holiday package deals, you can be sure that everything is organized meticulously and according to what you really need. Nonetheless, you would still need to carefully select the package that would fit your needs. Review the following tips in getting packages that are reasonably priced. · Normally, luxury tour packages include accommodation, flight travel and transportation to individual tourist destinations. It would be best to choose the complete package so you won’t have to worry about other vacation elements. In addition to that, these are the packages that have the biggest discounts. · You can get big mark down prices, if you will purchase more packages. It is not a bad idea to share the wonderful moment with your loved ones. By doing so, you would not only enjoy, you will also save more money. You can even use your savings for other activities on your vacation. · It would be best to know how much you are willing to pay for the luxury tour packages. You can already work around your budget. You have to stick to your budget. If not, you might end up spending a lot and you will be left with less money for your vacation. · Prices may vary depending on the destination of the tour. You can do a research about places that are attractive yet inexpensive. There are thousands of destinations and you just have to choose wisely. · There are packages that include recreational activities. This means that you are paying for all the activities when you purchase these packages. The right thing to do is to make sure that the activities that are included would be the ones that you really enjoy. There is no sense in paying for activities that will not really make your vacation memorable. If you are going with friends, you should also consider their preferences so that you can be sure that everyone will enjoy the trip. There are other ways on how you can be sure that you are getting the best deal for your luxury holiday vacation. No matter how you choose to do it, you have to get adequate information about the packages. This will help you determine whether it is worth the price.

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