Pfizer scientists are studying whether a THIRD vaccine shot can offer protection

Pfizer Inc announced on Thursday it has begun studying a third dose of its COVID-19 vaccine, part of a strategy to guard against mutated versions of the coronavirus.

Health authorities say first-generation COVID-19 vaccines still protect against variants that are emerging in different parts of the world including the UK and South Africa.

But manufacturers are now starting to prepare in case a more vaccine-resistant mutation comes along.

Pfizer and its German partner, BioNTech SE, said it will offer a third dose to 144 volunteers, drawing from people who participated in the vaccine’s early-stage U.S. testing last year. 

It wants to determine if an additional booster shot given six to 12 months after the first two doses would rev up the immune system enough to ward off a mutated virus.  

Pfizer Inc and its German partner BioNTech are studying a third dose of their coronavirus vaccine, which is aimed at protecting against variants (file image)

Pfizer Inc and its German partner BioNTech are studying a third dose of their coronavirus vaccine, which is aimed at protecting against variants (file image)

Pfizer Inc and its German partner BioNTech are studying a third dose of their coronavirus vaccine, which is aimed at protecting against variants (file image)

Variants spreading across the U.S. including the one from South Africa (purple dot),are better at evading antibodies from vaccine than earlier strains of the virus

Variants spreading across the U.S. including the one from South Africa (purple dot),are better at evading antibodies from vaccine than earlier strains of the virus

Variants spreading across the U.S. including the one from South Africa (purple dot),are better at evading antibodies from vaccine than earlier strains of the virus

Researchers believe if the shot is given six to 12 months after the first two doses, it may help stimulate the immune system enough to ward off a mutated virus as the U.S. vaccinates about 1.2 million people per day

Researchers believe if the shot is given six to 12 months after the first two doses, it may help stimulate the immune system enough to ward off a mutated virus as the U.S. vaccinates about 1.2 million people per day

Researchers believe if the shot is given six to 12 months after the first two doses, it may help stimulate the immune system enough to ward off a mutated virus as the U.S. vaccinates about 1.2 million people per day

The vaccine candidate from Pfizer and BioNTech uses part of the pathogen’s genetic code called messenger RNA, or mRNA, to get the body to recognize the coronavirus and attack it if a person becomes infected.

In the jab, known as BNT162b2, the mRNA encodes for all of the spike protein found on the outside of the virus that it uses to enter and infect cells. 

It was authorized for emergency use by the U.S. Food and Drug Administration (FDA) after a clinical trial involving 44,000 volunteers found the shot was 95 percent effective at preventing symptomatic COVID-19.

The two-dose Pfizer-BioNTech vaccine was the first authorized for use in the U.S., in December, after a large global study in 44,000 people found the shot was safe and 95% effective at protecting against symptomatic

However, the company’s current two-dose regimen produced a weaker immune response against the variant. 

Recently, in a study punished in the New England Journal of Medicine, Pfizer teamed up with the University of Texas Medical Branch to test its vaccine against the South African variant, known as B.1.351.

They found that only one-third of its neutralizing antibodies were activated compared with its effect on the most common version of the virus prevalent in U.S. trials.

However, the pharmaceutical giant said the actual efficacy of its vaccine against the South African variant is yet to be determined.  

‘While we have not seen any evidence that the circulating variants result in a loss of protection provided by our vaccine, we are taking multiple steps to act decisively and be ready in case a strain becomes resistant to the protection afforded by the vaccine,’ Pfizer CEO Albert Bourla said in a statement.

‘At the same time, we are making the right investments and engaging in the appropriate conversations with regulators to help position us to potentially develop and seek authorization for an updated mRNA vaccine or booster if needed.’ 

It currently unclear when Pfizer and BioNTech will have results on the efficacy of the booster shots but, during an earnings call earlier this month, Pfizer R&D chief Mikael Dolsten said preliminary data may be available in early summer.  

Pfizer and BioNTech are also are tweaking their vaccine recipe. 

The companies are in discussions with U.S. and European regulators about a study to evaluate doses updated to better match variants such as B.1.351.

Pfizer’s approach is different from than of Moderna Inc, which announced yesterday it had made a new vaccine as a booster and had sent doses to the National Institutes of Health for testing.

Moderna’s vaccine, like Pfizer’s, is made with new mRNA technology and also needs to be stored at freezing temperatures.

Also like Pfizer, Moderna’s shot was found to be less effective against the strain.

In a study published in The New England Journal of Medicine, researchers found a six-fold decrease in antibody response against the variant from Moderna’s jab. 

Recently, the FDA said any company developing a booster would have their results analyzed quickly and would not need large efficacy trials to be approved.

Link hienalouca.com

Advertising:

Tips to Find Low Priced Luxury Holiday Package Deals Fast

For most families, it has already been a common practice to spend the Holiday season in a foreign location. This is caused by the aviation market changes which have given a lot of benefits for people who travel a lot. Airfares going to different tourist destinations are becoming more inexpensive. What does this mean? If there is a perfect time to purchase luxury holiday package deals, now it the right time! Based on the market trend nowadays, you can save both money and time when you go for a luxury holiday. There are countless offers that combine travel and accommodation in one package which is a lot cheaper than getting separate deals. Aside from that, it is also risky to individually book the services that you need for the vacation. You might end up missing out on some important details of the trip. Unlike when you take advantage of luxury holiday package deals, you can be sure that everything is organized meticulously and according to what you really need. Nonetheless, you would still need to carefully select the package that would fit your needs. Review the following tips in getting packages that are reasonably priced. · Normally, luxury tour packages include accommodation, flight travel and transportation to individual tourist destinations. It would be best to choose the complete package so you won’t have to worry about other vacation elements. In addition to that, these are the packages that have the biggest discounts. · You can get big mark down prices, if you will purchase more packages. It is not a bad idea to share the wonderful moment with your loved ones. By doing so, you would not only enjoy, you will also save more money. You can even use your savings for other activities on your vacation. · It would be best to know how much you are willing to pay for the luxury tour packages. You can already work around your budget. You have to stick to your budget. If not, you might end up spending a lot and you will be left with less money for your vacation. · Prices may vary depending on the destination of the tour. You can do a research about places that are attractive yet inexpensive. There are thousands of destinations and you just have to choose wisely. · There are packages that include recreational activities. This means that you are paying for all the activities when you purchase these packages. The right thing to do is to make sure that the activities that are included would be the ones that you really enjoy. There is no sense in paying for activities that will not really make your vacation memorable. If you are going with friends, you should also consider their preferences so that you can be sure that everyone will enjoy the trip. There are other ways on how you can be sure that you are getting the best deal for your luxury holiday vacation. No matter how you choose to do it, you have to get adequate information about the packages. This will help you determine whether it is worth the price.

(Total views: 96 Time, 1 visits per day)

Leave a Reply