TMZ reports that Mathers Jr. suffered a heart attack while at home near Fort Wayne, Indiana, this week.
The 46-year-old rapper, born Marshall Bruce Mathers III, regularly rapped about being abandoned by his biological father and having never met him in person.
No relationship: Eminem’s father, Marshall Bruce Mathers Jr., who abandoned him as a baby, has died aged 67. The rapper is pictured here in 2008
His songs My Name Is and Cleanin’ Out My Closet feature lyrics about his grudge towards his dad.
Eminem’s mother Debbie married Bruce when she was just 15 and he was 22 but they split shortly after he was born.
While Debbie and Eminem stayed in Detroit, Bruce moved to California where he started a new family, fathering two children.
Bruce had spoken out in 2001 to say he had tried to reach out to his son but blamed Eminem’s mother for keeping him away.
Eminem had said in interviews that he would write his dad letters as a child but they would come back ‘return to sender’.