Both teams need a victory at Wembley to have any chance of progressing to the knockout stages with each side currently on just one point from their opening three matches.
PSV fans have been snapped getting into the spirit of things and could be seen sinking a pint or three before making their trip to the stadium ahead of kick-off.
PSV Eindhoven fans have started to make the most of their visit to London on Tuesday night
Fans gathered in Covent Garden ahead of their Champions League clash against Tottenham
PSV fans have been snapped getting into the spirit of things in the busy tourist area of London
One supporter jumped in a traditional red phone box for a snap as his friend took the picture
Mark van Bommel’s side earned a 2-2 draw with the
That result will have given those PSV fans who have travelled to the English capital a lot of hope as they drank in the early hours of Tuesday night.
They all seemed to be in good spirits as hundreds of supporters made themselves at home outside one of the many pubs in the busy tourist area of the city.
A number of fans also posed for photos together while one jumped in a traditional red phone box for a snap and another cradled a box full of bottle of beer.
They could be seen sinking a pint or three before making their trip to the stadium
Hundreds of supporters made themselves at home inside one of the many pubs in the area
Keen to take his alcohol on the move, one supporter cradled a box full of bottles of beer
The Dutch champions are unbeaten in domestic competition this season but face a tough task
The Dutch champions are unbeaten in domestic competition this season, with their only two defeats coming against Group B rivals Barcelona and Inter Milan.
PSV come into the game on the back of a 1-0 Eredivise victory over Vitesse on Saturday, which was their 11th consecutive win and put them five points clear of second-place Ajax.
Only a win will keep alive Tottenham’s slim hopes of qualifying from Champions League Group B, while a defeat could leave Mauricio Pochettino’s side heading for a fourth-place finish and complete elimination from Europe this season.
With Champions League progress unlikely and Spurs relying on other results to help them reach the knockout phase, thousands of tickets remain unsold for the match, which will kick off at 8pm.